Dolastatin 15 (trifluoroacetat

一种肽；在1nM浓度下诱导细胞周期停滞于G2/M期并抑制JVM-2和EHEB人类B细胞白血病细胞的增殖；抑制RPMI-8826、U266和IM-9人类多发性骨髓瘤细胞(IC50s=0.5-1nM)以及一组结肠和卵巢癌细胞系(IC50s=0.031-1.8nM)的增殖；在每天5.25mg/kg的剂量下降低CH1小鼠异种移植模型中的肿瘤生长。A peptide; induces cell cycle arrest at the G2/M phase and inhibits proliferation of JVM-2 and EHEB human B cell leukemia cells at 1 nM; inhibits proliferation of RPMI-8826, U266, and IM-9 human multiple myeloma cells (IC50s = 0.5-1 nM), as well as a panel of colon and ovarian cancer cell lines (IC50s = 0.031-1.8 nM); reduces tumor growth in a CH1 mouse xenograft model at 5.25 mg/kg per day.