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文献和实验The Androgen Receptor CAG Repeat and Prostate Cancer Risk
The androgen receptor (AR) gene comprises eight exons located at chromosome Xq11-12 and encodes an mRNA transcript of approx 11 kb (1 –5 ). Situated within exon 1 of the AR gene is a polymorphic CAG trinucleotide repeat, which encodes
. Purification of full-length androgen receptor (AR) is complicated by its low abundance, instability in the absence of androgen, and size and charge similarities with other nuclear proteins. Previous approaches to steroid hormone receptor purification
Polyclonal and Monoclonal Antibodies in Clinic
the highly evolved machinery of the immune system to produce structurally and functionally complex molecules such as antibodies from a single B clone, heralding the era of monoclonal antibodies. Most of the antibodies currently in the clinic, target
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