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IL-12B/ IL-12 p40, Human, Reco

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  • ¥1380 - 25680
  • 普诺赛
  • PCK172
  • 国产
  • 2025年07月30日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10μg/500μg/50μg/1mg

    规格:10μg产品价格:¥1380.0
    规格:500μg产品价格:¥17480.0
    规格:50μg产品价格:¥3680.0
    规格:1mg产品价格:¥25680.0

    产品信息

    别名 Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2
    物种 Human
    表达宿主 Human Cells
    序列信息  Ile23-Ser328
    检索号 P29460
    分子量 34.6 kDa
    表观分子量 40-47 kDa

    产品特性

    纯度 >95% as determined by reducing SDS-PAGE.
    内毒素 < 1.0 EU per µg as determined by LAL test.
    保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
    运输 Ambient temperature or ice pack.
    制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
    复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

    背景介绍

    Interleukin-12 subunit beta (IL-12B) belongs to the type I Cytokine Receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a Cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD Cytokine Receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/ effector Th1 cells to mediate long-term protection to an intracellular pathogen.

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    图标文献和实验
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    • Procedure for Culturing BG01V Human Embryonic Stem Cells with Human Feeder Cell Conditioned Medium

      at 200 x g for 4 minutes. Remove the supernatant and gently flick the pellet. Resuspend the pellet in an appropriate amount of Human Feeder Cell Conditioned Medium supplemented with 4 ng/mL of recombinant human FGF basic. Add

    • Thl型细胞因子与介导细胞免疫的细胞因子

      IFN;并能激活中性粒细胞,增强它们的呼吸爆发,但效果弱于TNF或LT;IFN-7还是血管内皮细胞的激活因子,促进CD4T细胞黏附和形态改变,有利于淋巴细胞穿过血管。       2.IL-12  激活形式的IL-12是p35和p40两个亚单位通过二硫键连接而成的异二聚体。很多细胞能合成p35,但只有激活的单核/巨噬细胞才能合成p40IL-12作用的靶细胞主要是T细胞和NK细胞。生物学功能包括:     ①刺激T细胞和NK细胞分泌IFN-7;     ②促进CD

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