IL-1R-1/ CD121a, Human, Recomb

Interleukin 1 Receptor, type I (IL-1R1) is an Interleukin Receptor that belongs to the Interleukin-1 Receptor family. IL-1R1 is an 80 kDa transmembrane Protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a Cytokine Receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many Cytokine induced immune and inflammatory responses. It binds to Interleukin-1 associates with the corecptor IL1RAP to form the high affinity Interleukin-1 Receptor complex which mediates Interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the Receptor/ coReceptor subunits. It also binds Ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 Receptor accessory Protein that can heterodimerize with the Type I Receptor in the presence of IL1α or IL1β but not IL1ra, was identified. Recombinant IL1 soluble Receptor Type I is a potent antagonist of IL1 action.