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IL-13/P600,Mouse,Recombinant

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  • ¥1780 - 27980
  • 普诺赛
  • PCK251
  • 国产
  • 2025年07月30日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 库存

      现货

    • 供应商

      上海经科化学科技有限公司

    • 规格

      500μg/10μg/50μg/1mg

    规格:500μg产品价格:¥18980.0
    规格:10μg产品价格:¥1780.0
    规格:50μg产品价格:¥4980.0
    规格:1mg产品价格:¥27980.0

    产品信息

    别名 P600
    物种 Mouse
    表达宿主 E.coli
    序列信息 MPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGFCVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHFITKLLSYTKQLFRHGPF with polyhistidine tag at the C-terminus.
    检索号 P20109.1
    分子量 13.06 kDa
    表观分子量 11 kDa
    标签 His-tag at the C-terminus
    生物活性 Measure by its ability to induce TF-1 cells proliferation. The ED50 for this effect is <4 ng/mL. The specific activity of recombinant mouse IL-13 is > 2.5 x 10^5 IU/mg.

    产品特性

    纯度 >95% as determined by SDS-PAGE. Ni-NTA chromatography.
    内毒素 <0.1 EU per 1 μg of the protein by the LAL method.
    保存 Lyophilized protein should be stored at -5~-20°C for 1 year. Upon reconstitution,store at 2-8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g.0.1% BSA,10%FBS,5%HSA or 5% trehalose solution), protein aliquots should be stored at -5~-20°C or -80°C for 3-6 months.
    运输 Ambient temperature or ice pack.
    制剂 The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4.
    复融 It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL.Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

    背景介绍

    Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31 with a length of 1.4kb. It has a mass of 13 kDa and folds into 4 alpha helical bundles. The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence homology to IL-4 and is capable of IL-4 independent signaling. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, Natural killer T cell, Mast cell, Basophil cells, Eosinophil cells and Nuocyte cells. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma.

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