- ￥1
- CLOUD-CLONE
- MAC918Hu23
- 2025年07月09日
- WB; IHC; ICC; IP.
- 小鼠
- Human，人
11 年钻石会员
企业认证
相关产品推荐更多 >
Polyclonal Antibody to Alanine Glyoxylate Aminotransferase (AGXT)-PAC287Ra01
￥1Polyclonal Antibody to Chloride Intracellular Channel Protein 1 (CLIC1)-PAC390Hu01
￥1Polyclonal Antibody to Glutathione Peroxidase 4 (GPX4)-PAC994Hu01
￥1Polyclonal Antibody to Prostaglandin E Synthase 2 (PTGES2)-PAA905Mu01
￥1Polyclonal Antibody to Phospholipase C Delta 3 (PLCd3)-PAD838Hu01
￥1
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
杭州昊鑫生物
- 库存：
100
- 靶点：
FGF21
- 克隆性：
单克隆
- 保质期：
12个月
- 抗体英文名：
Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21)
- 抗体名：
FGF21)单克隆抗体
- 标记物：
无标记物
- 宿主：
小鼠
- 适应物种：
Human，人
- 亚型：
IgG2b Kappa
- 形态：
液体
- 应用范围：
WB; IHC; ICC; IP.
- 保存条件：
-20°
- 浓度：
1mg/mL
- 规格：
10ul（限杭州地区终端客户）
成纤维细胞生长因子21(FGF21)单克隆抗体
Monoclonal Antibody to Fibroblast Growth Factor 21 (FGF21)
- 编号MAC918Hu23
- 物种Homo sapiens (Human，人) 相同的名称，不同的物种。
- 来源单抗制备
- 宿主小鼠
- 效价(克隆号)C6
- Ig亚型IgG2b Kappa
- 纯化方式蛋白A + 蛋白G亲和纯化
- 标记物无标记物
- 免疫原RPC918Hu01-成纤维细胞生长因子21(FGF21)重组蛋白
- 缓冲液成份0.01M 磷酸盐缓冲液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
- 性状液体
- 浓度1mg/mL
- 且适物种-
- 应用WB; IHC; ICC; IP.
- 下载英文说明书 中文说明书
特异性
该抗体是针对FGF21的小鼠单克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别FGF21。
用法
Western blotting: 0.5-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.
储存
经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。
参考文献
| 杂志 | 参考文献 |
| Lipids in Health and Disease | Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [Lipidworld: source] |
| Endocrinology | Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression [Endocrine:Source] |
| Biochemical and Biophysical Research Communications | Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH [Pubmed:25449271] |
| Free Radic Biol Med | Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway [PubMed: 25843656] |
| Journal of diabetes and its complications | Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria. [pubmed:27916484] |
| American journal of the medical sciences | Association of Bone Metabolic Markers With Diabetic Retinopathy and Diabetic Macular Edema in Elderly Chinese Individuals With Type 2 Diabetes Mellitus [pubmed:29078839] |
| Frontiers in Physiology | Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21 [Pubmed:29593555] |
| Некоторые аспекты транспортной системы метаболизма железа в зависимости от степени синдрома перегрузки железом у детей с хроническим … [] | |
| Physiol Res | Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease. [Pubmed: 32469231] |
| Chinese Journal of Osteoporosis | 2 型糖尿病患者血清FGF21, 骨连结蛋白和骨转换指标的相关性研究. [] |
| Sci Rep | Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats [33833309] |
| Nutrients | The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose [] |
| Medicine (Baltimore) | Association of serum fibroblast growth factor 21 with kidney function in a population-based Chinese cohort [34918690] |
| Annals of Agricultural and Environmental Medicine | Oxidative stress-induced growth inhibitor 1 in alcohol-induced liver cirrhosis [34969228] |
| J Magn Reson Imaging | Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine‐Choline‐Deficient Diet‐Induced Nonalcoholic Fatty Liver … [Pubmed:35212074] |
| Lab Invest | Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury [Pubmed:35488034] |
| Molecular Biology Reports | Umbilical cord-derived mesenchymal stem cell conditioned medium reverses neuronal oxidative injury by inhibition of TRPM2 activation and the JNK signaling … [Pubmed:35585377] |
| High Circulating Fibroblast Growth Factor-21 Levels as a Prognostic Marker in Fatty Pancreas Patients [] |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
参考文献
| 杂志 | 参考文献 |
| Lipids in Health and Disease | Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [Lipidworld: source] |
| Endocrinology | Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast growth factor 21 expression [Endocrine:Source] |
| Biochemical and Biophysical Research Communications | Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH [Pubmed:25449271] |
| Free Radic Biol Med | Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway [PubMed: 25843656] |
| Journal of diabetes and its complications | Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria. [pubmed:27916484] |
| American journal of the medical sciences | Association of Bone Metabolic Markers With Diabetic Retinopathy and Diabetic Macular Edema in Elderly Chinese Individuals With Type 2 Diabetes Mellitus [pubmed:29078839] |
| Frontiers in Physiology | Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21 [Pubmed:29593555] |
| Некоторые аспекты транспортной системы метаболизма железа в зависимости от степени синдрома перегрузки железом у детей с хроническим … [] | |
| Physiol Res | Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease. [Pubmed: 32469231] |
| Chinese Journal of Osteoporosis | 2 型糖尿病患者血清FGF21, 骨连结蛋白和骨转换指标的相关性研究. [] |
| Sci Rep | Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats [33833309] |
| Nutrients | The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose [] |
| Medicine (Baltimore) | Association of serum fibroblast growth factor 21 with kidney function in a population-based Chinese cohort [34918690] |
| Annals of Agricultural and Environmental Medicine | Oxidative stress-induced growth inhibitor 1 in alcohol-induced liver cirrhosis [34969228] |
| J Magn Reson Imaging | Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine‐Choline‐Deficient Diet‐Induced Nonalcoholic Fatty Liver … [Pubmed:35212074] |
| Lab Invest | Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury [Pubmed:35488034] |
| Molecular Biology Reports | Umbilical cord-derived mesenchymal stem cell conditioned medium reverses neuronal oxidative injury by inhibition of TRPM2 activation and the JNK signaling … [Pubmed:35585377] |
| High Circulating Fibroblast Growth Factor-21 Levels as a Prognostic Marker in Fatty Pancreas Patients [] |
相关实验
常言道，喝点小酒莫喝醉，少点熬夜早点睡，尽力活到 100 岁。为个人健康着想，喝酒应适量且节制，但生活中难免有人喝得酩酊大醉，甚至喝酒误事，酒后失态，给自己和他人带来无穷无尽的麻烦。 成熟水果和花蜜中单糖自然发酵产生的乙醇消耗会导致中毒，损害活动能力和判断力，因此食用果糖和其他单糖的动物已经进化出肝酶来分解乙醇。 在最新的研究中，研究人员又发现了一种新的醒酒分子——成纤维细胞生长因子 21（FGF21）。 2023 年 3 月 7 日，德州大学西南医学中心 Steven
CD21 分子 CD21 常用单克隆抗体或代号： B2,OKB- 1;(CR2) 主要表达细胞： Pre- B,B,FDC [B] 分子质量(kDa)和结构： p145(RCA) 功 能： C3d/EBV受体,B细胞活化,结合sCD23,信号转导 CD21 Aka CR2, C3d receptor, EBV receptor Binds to Epstein Barr
明明是必须氨基酸，吃了却有害健康，喻德阳等 Cell 子刊揭示其中代谢机制
了 FOXA2 目标之一的 FGF21， 也在低异亮氨酸组的小鼠肝脏中，出现了显著的上调。尽管此前并没有文献报道 FGF21 与 BCAA 之间存在关系，但 FGF21 在低异亮氨酸组小鼠各个重要代谢组织的上调让研究人员认为其作用并不简单。在低异亮氨酸组小鼠的腹股沟白色脂肪组织（iWAT）中出现的代谢变化与 FGF21 上调，也进一步印证了作者的猜想。图片来源：Cell Metabolism敲除 FGF21 后，低异亮氨酸饮食对小鼠的代谢起到的改善作用被显著的降低，则直接证明了 FGF21 与异亮氨酸之间
技术资料暂无技术资料 索取技术资料
文献支持
成纤维细胞生长因子21(FGF21)单克隆抗体
￥1
