- ￥1280 - 2180
- Tanda
- 中国
- TD-30375
- 2025年11月07日
- ELISA、IHC、WB
- Mouse
- Human
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- 详细信息
- 技术资料
- 免疫原：
peptide
- 亚型：
IgG1
- 形态：
Liquid
- 保存条件：
-20℃
- 克隆性：
mAb
- 适应物种：
Human
- 保质期：
1年
- 目录编号：
TD-30375
- 级别：
科研级
- 库存：
88
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA、IHC、WB
- 靶点：
详询
- 抗体英文名：
Mouse Monoclonal Antibody to SHH
- 抗体名：
CD38
- 规格：
100ul/50ul
| 规格： | 100ul | 产品价格： | ￥2180.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥1280.0 |
Mouse Monoclonal Antibody to SHH
Description | |
| This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. | |
Specification | |
| Aliases | TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5 |
| Entrez GeneID | 6469 |
| Swissprot | Q15465 |
| clone | 5H4 |
| WB Predicted band size | 49.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | Purified recombinant fragment of human SHH (AA: 26-161) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application | |
| WB | 1/500 - 1/2000 |
| IHC | 1/200 - 1/1000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image | |
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Mouse Monoclonal Antibody to SHH
￥1280 - 2180
