无动物成分重组人调蛋白β-1

无动物成分重组人调蛋白β-1 英文名称：Animal-Free Recombinant Human Heregulinbeta-1 规格：50ug 价格：￥3,201 货号：AF-100-03-50ug 不含动物成分蛋白/ANIMAL-FREE PROTEINS 产品描述： Animal-Free Recombinant Human Heregulinβ-1 Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues). Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Neuregulin1 (NRG1-β1), Neu differentiation factor (rat), HRG, HRG1-β1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine Receptor Inducting Activity), glial growth factor AA Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Animal-Free Recombinant Human Heregulinβ-1 Biological Activity Graph Calculated Molecular Weight: 7.5 kDa Accession Number: Q02297 Gene ID: 3084 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse, Rat无动物成分重组人调蛋白β-1 齐一生物代理PeproTech的产品原装正品质量、到货快捷、专业的物流配送、专人全程跟踪订单、确保货物安全、准确及时地送达指定地点、欢迎您的来电咨询！ PeproTech重组蛋白与科学服务领域是由经验丰富的蛋白质科学家开发出来的，因此能够为制备抗体提供高品质的原料。重组蛋白到抗原亲和纯化的抗体拥有自己的研发系统，能够保证产品的高品质。 PeproTech的高品质细胞因子生产商，产品包括原核和真核细胞表达的高质量的重组蛋白，PeproGMP®细胞因子，无动物成分细胞因子，生长因子和细胞因子，趋化因子，神经营养因子等，抗原亲和纯化的多克隆抗体，生物素标记的多克隆抗体，单克隆/多克隆抗体，对照抗体，ABTS ELISA试剂盒，TMB ELISA试剂盒，酶联免疫吸附开发试剂盒，相关培养基等。