重组人Neuroserpin

重组人Neuroserpin 英文名称：Recombinant Human Neuroserpin 规格：5ug 价格：￥1,134 货号：130-14-5ug RUO PROTEINS Neuroserpin is an inhibitory serpin that is expressed predominantly in the central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggests that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis, and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory (i.e. cerebral cortex, hippocampus, and amygdala.) The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB). Recombinant Human Neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino-acid residues. Source: E.coli Synonyms: Serpin I1, Protease inhibitor 12 AA Sequence: MTGATFPEEA IADLSVNMYN RLRATGEDEN ILFSPLSIAL AMGMMELGAQ GSTQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ NGFHVNEEFL QMMKKYFNAA VNHVDFSQNV AVANYINKWV ENNTNNLVKD LVSPRDFDAA TYLALINAVY FKGNWKSQFR PENTRTFSFT KDDESEVQIP MMYQQGEFYY GEFSDGSNEA GGIYQVLEIP YEGDEISMML VLSRQEVPLA TLEPLVKAQL VEEWANSVKK QKVEVYLPRF TVEQEIDLKD VLKALGITEI FIKDANLTGL SDNKEIFLSK AIHKSFLEVN EEGSEAAAVS GMIAISRMAV LYPQVIVDHP FFFLIRNRRT GTILFMGRVM HPETMNTSGH DFEEL Purity: ≥ 96% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 μg/ml. Calculated Molecular Weight: 44.8 kDa Accession Number: Q99574 Gene ID: 5274 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Rat重组人Neuroserpin 是齐一生物公司重点推广产品，齐一生物代理PeproTech的产品原装正品质量，我公司有专业的人员进行全程指导，请放心购买、发货时均会附上质检报告单、使用说明书和推荐用法用量、提供正规发票欢迎来电咨询！ PeproTech于1988年创立于美国，Peprotech的产品具有很高的性价比，这些细胞因子应用于生命科学研究；在众多高水平的实验室和研究机构中广泛使用。截至2013年底，已被13,000篇SCI文献引用；取得了细胞因子产品领域居于地位。 PeproTech重组蛋白与科学服务领域是由经验丰富的蛋白质科学家开发出来的，因此能够为制备抗体提供高品质的原料。重组蛋白到抗原亲和纯化的抗体拥有自己的研发系统，能够保证产品的高品质。