nsp12-IN-1

nsp12-IN-1 产品活性：Nsp12-IN-1 是一种核苷类似物。Nsp12-IN-1 可以阻断病毒 RNA 的合成，抑制病毒复制。Nsp12-IN-1 可用于泛冠状病毒的研究。 产品来源： www.medchemexpress.cn/nsp12-in-1.html 研究领域：Anti-infection 作用靶点：SARS-CoV In Vitro: Nsp12-IN-1 has a high selectivity index and is less toxic to cells at effective antiviral concentrations, showing antiviral activity against SARS-CoV-2. In Vivo: Nsp12-IN-1 (2 mg/kg, i.v.; 30mg/kg p.o.; 24h) improves oral bioavailability, but the absolute bioavailability of these compounds remains low in female Balb-c mice. Pharmacokinetic Analysis in female Balb-c mice Dosed compound Route Dose (mg/kg) AUClast (ng•h/mL) T1/2 (h) Tmax (h) Cmax (ng/mL) F (%) 10n i.v. 2 118 1.2 0.50 55 / 10n p.o. 30 171 4.3 2.0 49 9.6 12a p.o. 30 504 1.5 1.0 190 28.4 12b p.o. 30 847 3.4 0.67 301 47.7 相关产品：Chloroquine | Dexamethasone | Thapsigargin | ALC-0315 | Imatinib | Nirmatrelvir | Aloxistatin | Remdesivir | Imiquimod | Paquinimod | Hydroxychloroquine | Brequinar | GSK3326595 | Molnupiravir | Auranofin | Ritonavir | Methylprednisolone | Favipiravir | Ivermectin | Emodin | Punicalagin | Camostat mesylate | Asunaprevir | Cepharanthine | Zotatifin | Grazoprevir | EIDD-1931