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Human HER3(C00Y)

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  • ￥400 - 13000
  • SinoBio
  • 国产
  • C00Y
  • 2026年04月28日
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    上海经科化学科技有限公司
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件：

      蛋白表达区间:Ser20-Thr643

    • 保质期：

      See instructions

    • 英文名：

      标签:C-6His

    • 库存：

      表达系统:Human Cells

    • 供应商：

      上海经科化学科技有限公司

    • 规格：

      10ug/50ug/500ug/1mg

    规格：10ug产品价格：￥400.0
    规格：50ug产品价格：￥1200.0
    规格：500ug产品价格：￥8670.0
    规格：1mg产品价格：￥13000.0
    产品描述
    Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3 is produced by our Mammalian expression system and the target gene encoding Ser20-Thr643 is expressed with a 6His tag at the C-terminus.
    蛋白编号
    P21860
    产品别称
    Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3
    偶联
    Unconjugated
    分子量
    69.5 KDa
    表观分子量
    85-100 KDa, reducing conditions
    剂型描述
    Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH7.4.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    生物活性-BLI
    Loaded Human NRG1Beta (245AA)(Cat#C753) on APS Biosensor, can bind Human HER3-His(Cat#C00Y) with an affinity constant of 15 nM as determined in BLI assay. (Regularly tested)
    运输条件
    • The product is shipped on dry ice/polar packs.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.
    产品背景
    Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.

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    图标文献和实验
    该产品被引用文献

    Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.

    相关实验

    • Exploring Human Metabolites Using the Human Metabolome Database

      , J.S., Bocchini, C.A., and McKusick, V.A. 2005. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33:D514‐D517.   

    • Access Guide to Human Proteinpedia

      ., Ramachandra, Y.L., Acharya, P.K., Ranganathan, P., Chaerkady, R., Keshava Prasad, T.S., and Pandey, A. 2009. Human Proteinpedia: A unified discovery resource for proteomics research. Nucleic Acids Res. 37:D773‐D781.

    • Introduction of human 14-3-3 proteins

      whose members have been shown to activate tyrosine and tryptophan hydroxylases,inhibit protein kinase C and possess phospholipase A2 activity in vitro.We have isolated and analyzed a 14-3-3 protein cDNA clone (H14-3-3)from a human fetal brain cDNA library

    查看更多相关实验 >

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    文献支持
    Human HER3(C00Y)
    ￥400 - 13000