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Human TRAIL

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  • ¥400 - 7040
  • SinoBio
  • 国产
  • C022
  • 2025年12月21日
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      蛋白表达区间:Arg115-Gly281

    • 保质期

      See instructions

    • 英文名

      标签:Tag free

    • 库存

      表达系统:E.coli

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥400.0
    规格:50ug产品价格:¥1120.0
    规格:500ug产品价格:¥4920.0
    规格:1mg产品价格:¥7040.0
    产品描述
    Recombinant Human TNF-Related Apoptosis-Inducing Ligand is produced by our E.coli expression system and the target gene encoding Arg115-Gly281 is expressed.
    蛋白编号
    P50591
    产品别称
    Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
    偶联
    Unconjugated
    分子量
    19.5 KDa
    表观分子量
    16 KDa, reducing conditions
    剂型描述
    Supplied as a 0.2 μm filtered solution of 40mM Tris-HCl, 300mM NaCl, 5%Trehalose, 5%Mannitol, 0.01%Tween80, 10%Glycerol, pH7.0.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    纯度-SEC-HPLC
    Greater than 95% as determined by SEC-HPLC. (Regularly tested)
    生物活性-Cell Based Assay
    Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 1-10 ng/ml. (QC verified)
    运输条件
    • The product is shipped on dry ice/polar packs.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.
    产品背景
    Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.

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    图标文献和实验
    该产品被引用文献

    Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.

    相关实验
    • 跟踪信息素 trail pheromone,trail markingpheromone

        蚁、蜜蜂、白蚁等社会性昆虫,从巢出来寻找猎物,归巢时,在路上涂擦分泌物作为道路标志,其他个体跟踪前往便可达到目的地。这种分泌物称为跟踪信息素。蚁是从杜氏腺( Dufour′ s gland)和毒腺分泌出来的,蜜蜂是从发香腺分泌出来的,其组成成分经分离鉴定为牛儿醇( geraniol)等。白蚁则从腹板腺( sternal gland)分泌的。跟踪信息素以外的物质,也有具有跟踪作用的化合物。  

    • Apoptosis Induction by TRAIL

      In 1995, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was identified on the basis of sequence homology to the other members of the TNF family (1 ). Like TNF and CD95 ligand (CD95L/FasL/ APO-1L), TRAIL (APO-2L

    • Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy

      , TNF-related apoptosis-inducing ligand (TRAIL), or Apo-2 ligand, has generated excitement because of its unique ability to induce apoptosis in a wide range of transformed cell lines but not in normal tissues. TRAIL is well tolerated when given

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    文献支持
    Human TRAIL
    ¥400 - 7040