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Human B7-2(C34K)

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  • ¥840 - 17600
  • SinoBio
  • 国产
  • C34K
  • 2025年12月22日
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    • 文献和实验
    • 技术资料
    • 保存条件

      蛋白表达区间:Ala24-Pro247

    • 保质期

      See instructions

    • 英文名

      标签:C-Fc

    • 库存

      表达系统:Human Cells

    • 供应商

      上海经科化学科技有限公司

    • 规格

      10ug/50ug/500ug/1mg

    规格:10ug产品价格:¥840.0
    规格:50ug产品价格:¥2520.0
    规格:500ug产品价格:¥12320.0
    规格:1mg产品价格:¥17600.0
    产品描述
    Recombinant Human T-lymphocyte activation antigen CD86 is produced by our Mammalian expression system and the target gene encoding Ala24-Pro247 is expressed with a human IgG1 Fc tag at the C-terminus.
    蛋白编号
    AAH40261.1
    产品别称
    T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2
    分子量
    52.5 KDa
    表观分子量
    70-110 KDa, reducing conditions
    剂型描述
    Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
    内毒素
    < 1 EU/µg as determined by LAL test.
    纯度-SDS-PAGE
    Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
    生物活性-BLI
    Loaded Recombinant Human B7-2 (C-Fc) (Cat#C34K) on Pro-A Biosensor, can bind Recombinant Human CTLA-4 (C-6His) (Cat#CP33) with an affinity constant of 7.72 nM as determined in BLI assay. (Regularly tested)
    运输条件
    • The product is shipped on dry ice/polar packs.
    • Upon receipt, store it immediately at the temperature listed below.
    保存条件
    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.
    产品背景
    The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

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    图标文献和实验
    该产品被引用文献

    The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

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    文献支持
    Human B7-2(C34K)
    ¥840 - 17600