DOTA-tris(acid)-amido-dPEG®-Ma

DOTA-tris(acid)-amido-dPEG®-Maleimide-50mg，DOTA-tris(acid)-amido-dPEG®₁₁-Maleimide-50 mg，DOTA-tris(acid)-amido-dPEG®-Maleimide-50mg,DOTA-tris(acid)-amido-dPEG®₁₁-Maleimide-50 mg

DOTA-tris(acid)-amido-dPEG®-Maleimide-50mg-DOTA-tris(acid)-amido-dPEG®₁₁-Maleimide-50 mg

产品货号：CCT-QBD-11167-50

产品规格：50mg

DOTA-三(酸)-酰胺基-dPEG ®11-马来酰亚胺，产品编号QBD-11167，通过中等长度(37个原子，43.5 μ m)、单分子量、离散PEG(dPEG®)连接体将硫醇反应性马来酰亚胺基团与流行的大环双官能螯合剂1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸(DOTA)连接。DOTA部分被设计成螯合镧系元素和某些稀土元素如钇的三价放射性同位素。马来酰亚胺基团在pH 6.5 - 7.5下在点击化学样反应中与硫醇化学选择性地反应。由于大环上的四个乙酸酯基团未受保护，因此该DOTA化合物应在合成过程结束时与目标分子缀合，此时将不进行进一步的反应。DOTA产品通常用于放射性药物学中的成像、诊断和治疗应用。

DOTA-tris(acid)-amido-dPEG®11-maleimide, product number QBD-11167, links a thiol-reactive maleimide group with the popular, macrocyclic, bifunctional chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) through a medium-length (37 atoms, 43.5 Å), single molecular weight, discrete PEG (dPEG®) linker. The DOTA moiety is designed to chelate trivalent radioisotopes of lanthanides and certain rare earth elements like yttrium. The maleimide group reacts chemoselectively with thiols at pH 6.5 – 7.5 in a click chemistry-like reaction. Because the four acetate groups on the macrocycle are unprotected, this DOTA compound should be conjugated to the target molecule at the end of the synthetic process when no further reactions will be carried out. DOTA products are commonly used in radiopharmacy in imaging, diagnostic, and therapeutic applications.The medium-length, amphiphilic, flexible dPEG® linker between the DOTA and the TFP ester moieties increases the hydrodynamic volume and water solubility of conjugate molecules. The increased hydrodynamic volume can reduce a conjugate molecule's renal clearance, thereby increasing serum half-life and reducing the dosage of the conjugate required for efficacy. Moreover, dPEG® is non-immunogenic, and the increased hydrodynamic volume helps reduce the immunogenicity of conjugated molecules.

DOTA-tris(acid)-amido-dPEG®-Maleimide-50mg-DOTA-tris(acid)-amido-dPEG®₁₁-Maleimide-50 mg

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