DOTA-三(酸)-酰胺-dPEG ®-溴乙酰酰胺-500

DOTA-三(酸)-酰胺-dPEG ®-溴乙酰酰胺-500 mg，DOTA-tris(acid)-amido-dPEG®₁₁-bromoacetamide-500 mg，DOTA-三(酸)-酰胺-dPEG ®-溴乙酰酰胺-500 mg,DOTA-tris(acid)-amido-dPEG®₁₁-bromoacetamide-500 mg

DOTA-三(酸)-酰胺-dPEG ®-溴乙酰酰胺-500 mg-DOTA-tris(acid)-amido-dPEG®₁₁-bromoacetamide-500 mg

产品货号：CCT-QBD-11152-500

产品规格：500mg

DOTA-三(酸)-酰胺基-dPEG ®11-溴乙酰胺，产品编号QBD-11152，通过单个分子量的离散聚乙二醇(dPEG®)连接体将大环1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸(DOTA)与硫醇反应性溴乙酰基结合，该硫醇反应性溴乙酰基通过酰胺键与dPEG®连接体偶联。接头含有38个原子，并且从与DOTA部分相邻的末端酰胺到与溴原子相邻的亚甲基的长度为43.9 μ m。该产品可用于放射成像和放射治疗应用。DOTA和溴乙酸酯基团之间的柔性、中等长度、单分子量dPEG®连接体用于许多目的。首先，dPEG®链中的每个乙二醇单元通过氢键结合获得多达三个水分子。因此，分子获得水溶性。其次，在水性环境如血液中，dPEG®增加dPEG®缀合物的流体动力学体积。在较大的流体动力学体积下，缀合物对肾排泄较不敏感，这意味着缀合物的有效性能需要较低剂量的诊断剂或治疗剂。第三，dPEG®是非免疫原性的，并且其大的流体动力学体积有助于降低缀合分子的免疫原性。

DOTA-tris(acid)-amido-dPEG®11-bromoacetamide, product number QBD-11152, combines the macrocycle 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) through a single molecular weight, discrete polyethylene glycol (dPEG®) linker to a thiol-reactive bromoacetyl group that couples to the dPEG® linker via an amide bond. The linker contains 38 atoms and is 43.9 Å long from the terminal amide adjacent to the DOTA moiety to the methylene group adjacent to the bromine atom. This product is useful in radioimaging and radiotherapeutic applications.The bromoacetate moiety (present as the bromoacetamide in QBD-11152) reacts chemoselectively, but not chemospecifically, with free thiol groups to form stable thioether bonds. The rate and specificity of bromoacetate for free thiols depends upon the pH of the reaction and the relative availability (compared to thiols) of other groups with which the bromoacetate moiety can react (for example, surface-accessible amines).DOTA is a highly popular bifunctional chelator used in a variety of diagnostic and therapeutic applications for the delivery of radionuclides, particularly lanthanide radionuclides and certain rare earth radioisotopes such as yttrium. DOTA is the preferred ligand for treatments using trivalent lanthanides because it binds the metal ions to form thermodynamically stable, kinetically inert complexes.The flexible, medium-length, single molecular weight dPEG® linker between the DOTA and the bromoacetate groups serves many purposes. First, each ethylene glycol unit in the dPEG® chain acquires up to three molecules of water through hydrogen bonding. Consequently, the molecule gains water solubility. Second, in aqueous environments such as blood, dPEG® increases the hydrodynamic volume of dPEG® conjugates. With larger hydrodynamic volumes, conjugates are less susceptible to renal excretion, meaning that lower doses of the diagnostic or therapeutic agent are needed for efficacious performance of the conjugate. Third, dPEG® is non-immunogenic, and its large hydrodynamic volume helps reduce the immunogenicity of conjugated molecules.

DOTA-三(酸)-酰胺-dPEG ®-溴乙酰酰胺-500 mg-DOTA-tris(acid)-amido-dPEG®₁₁-bromoacetamide-500 mg

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