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- 2025年07月14日
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Allo-aca TFA
产品活性：Allo-aca TFA 是一种瘦素肽模拟物，是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca TFA在多种体外和体内模型中阻断瘦素信号传导和作用。
产品来源： www.medchemexpress.cn/allo-aca-tfa.html
研究领域：Others
作用靶点：Others
In Vitro: Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM.Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells.
In Vivo: In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca TFA administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively.
相关产品：Digitonin | Lactate sodium | 5-Ph-IAA | FLAG peptide | Monocrotaline | TCEP hydrochloride | 3X FLAG peptide | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Ammonium tetrathiomolybdate(VI) | Phytohemagglutinin | Human IgG1 kappa, Isotype Control | Pertussis Toxin | MYLS22 | Hyaluronidase | Biotinyl tyramide | N,N-Dimethylformamide | Kifunensine | Lauryl maltose neopentyl glycol | Alkyne-phenol | 6-Aminonicotinamide | L-Tryptophan | OVA Peptide (323-339) | Potassium oxonate | OVA Peptide(257-264) TFA
产品活性：Allo-aca TFA 是一种瘦素肽模拟物，是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca TFA在多种体外和体内模型中阻断瘦素信号传导和作用。
产品来源： www.medchemexpress.cn/allo-aca-tfa.html
研究领域：Others
作用靶点：Others
In Vitro: Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM.Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells.
In Vivo: In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca TFA administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively.
相关产品：Digitonin | Lactate sodium | 5-Ph-IAA | FLAG peptide | Monocrotaline | TCEP hydrochloride | 3X FLAG peptide | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Ammonium tetrathiomolybdate(VI) | Phytohemagglutinin | Human IgG1 kappa, Isotype Control | Pertussis Toxin | MYLS22 | Hyaluronidase | Biotinyl tyramide | N,N-Dimethylformamide | Kifunensine | Lauryl maltose neopentyl glycol | Alkyne-phenol | 6-Aminonicotinamide | L-Tryptophan | OVA Peptide (323-339) | Potassium oxonate | OVA Peptide(257-264) TFA
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Allo-aca TFA
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