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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 英文名：
SB 751689A
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
702686-96-2
- 规格：
1 mg
Ronacaleret hydrochloride
产品活性：Ronacaleret hydrochloride (SB 751689A) 是一种口服活性、高效、选择性的钙感应受体 (CaSR) 拮抗剂，能刺激甲状旁腺释放内源性甲状旁腺激素。Ronacaleret hydrochloride (SB 751689A) 用于研究绝经后骨质疏松症.
产品来源： www.medchemexpress.cn/ronacaleret-hydrochloride.html
研究领域：GPCR/G Protein
作用靶点：CaSR
In Vitro: Ronacaleret inhibits OATP1B1 (IC50 = 11 μM) and OATP2B1 (IC50 = 12 μM)
In Vitro, whereas it does not inhibit BCRP.Ronacaleret is shown to inhibit the OATP1B1- and OATP1B3-mediated uptake of the probe substrate estradiol-glucuronide with relatively low potency (IC50 values of 11 and 60 μM, respectively).Ronacaleret inhibits OATP2B1-mediated rosuvastatin transport at pH 7.4 and pH 6.0, with IC50 values of 16 and 12 μM, respectively.
In Vivo: Ronacaleret (SB 751689, 3 mg/kg/day) preserves klotho expression and renal function with the reductions in serum phosphate and albuminuria in 5/6-nephrectomized rats.
相关产品：NPS-2143 | Cinacalcet | Etelcalcetide hydrochloride | Gadolinium chloride | Evocalcet | Tecalcet Hydrochloride | Calhex 231 hydrochloride | NPS 2390 | γ-L-Glutamyl-L-alanine | Ligustroflavone | Upacicalcet sodium | Calcium-Sensing Receptor Antagonists I | Strontium Ranelate | SB-423562 | Calindol hydrochloride | GSK3004774 | γ-Glutamylvaline | AC-265347 | CaSR antagonist-1 | Encaleret | Gamma-Glu-Abu | Ronacaleret | SB-423557
产品活性：Ronacaleret hydrochloride (SB 751689A) 是一种口服活性、高效、选择性的钙感应受体 (CaSR) 拮抗剂，能刺激甲状旁腺释放内源性甲状旁腺激素。Ronacaleret hydrochloride (SB 751689A) 用于研究绝经后骨质疏松症.
产品来源： www.medchemexpress.cn/ronacaleret-hydrochloride.html
研究领域：GPCR/G Protein
作用靶点：CaSR
In Vitro: Ronacaleret inhibits OATP1B1 (IC50 = 11 μM) and OATP2B1 (IC50 = 12 μM)
In Vitro, whereas it does not inhibit BCRP.Ronacaleret is shown to inhibit the OATP1B1- and OATP1B3-mediated uptake of the probe substrate estradiol-glucuronide with relatively low potency (IC50 values of 11 and 60 μM, respectively).Ronacaleret inhibits OATP2B1-mediated rosuvastatin transport at pH 7.4 and pH 6.0, with IC50 values of 16 and 12 μM, respectively.
In Vivo: Ronacaleret (SB 751689, 3 mg/kg/day) preserves klotho expression and renal function with the reductions in serum phosphate and albuminuria in 5/6-nephrectomized rats.
相关产品：NPS-2143 | Cinacalcet | Etelcalcetide hydrochloride | Gadolinium chloride | Evocalcet | Tecalcet Hydrochloride | Calhex 231 hydrochloride | NPS 2390 | γ-L-Glutamyl-L-alanine | Ligustroflavone | Upacicalcet sodium | Calcium-Sensing Receptor Antagonists I | Strontium Ranelate | SB-423562 | Calindol hydrochloride | GSK3004774 | γ-Glutamylvaline | AC-265347 | CaSR antagonist-1 | Encaleret | Gamma-Glu-Abu | Ronacaleret | SB-423557
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Ronacaleret,702686-96-2
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