- 询价
- MedChemExpress(MCE)
- 美国
- HY-163429
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
2883580-95-6
- 规格：
询盘
J-1149
产品活性：J-1149 是一种有效的 ALK5 抑制剂，IC50 值为 0.017 μM。J-1149 还表现出较弱的 p38α MAP 激酶抑制活性，IC50 值为 0.435 μM。J-1149可用于肝纤维化研究。
产品来源： www.medchemexpress.cn/j-1149.html
研究领域：TGF-beta/Smad | MAPK/ERK Pathway
作用靶点：TGF-β Receptor | p38 MAPK
In Vitro: J-1149 (compound 15g) (5-40 μM) efficiently inhibits extracellular matrix (ECM) deposition in TGF-β-induced hepatic stellate cells (HSCs), and eventually suppresses HSC activation. J-1149 (20 μM) inhibits the expression of α-SMA and collagen I stimulated by TGF-β.
In Vivo: J-1149 (compound 15g) shows a good pharmacokinetic (PK) profile with a favorable half-life (t1/2 = 9.14 h).
相关产品：SB-431542 | Dorsomorphin | Adezmapimod | A 83-01 | SB 202190 | Afatinib | Galunisertib | LDN193189 | RepSox | Doramapimod | Aspirin | LY2109761 | DMH-1 | Oxidopamine hydrobromide | SB 525334 | BI-3406 | Butyzamide | Vactosertib | Ergothioneine | Hesperetin | Muramyl dipeptide | C16-PAF | BMP signaling agonist sb4 | SB-505124 | Ralimetinib dimesylate
产品活性：J-1149 是一种有效的 ALK5 抑制剂，IC50 值为 0.017 μM。J-1149 还表现出较弱的 p38α MAP 激酶抑制活性，IC50 值为 0.435 μM。J-1149可用于肝纤维化研究。
产品来源： www.medchemexpress.cn/j-1149.html
研究领域：TGF-beta/Smad | MAPK/ERK Pathway
作用靶点：TGF-β Receptor | p38 MAPK
In Vitro: J-1149 (compound 15g) (5-40 μM) efficiently inhibits extracellular matrix (ECM) deposition in TGF-β-induced hepatic stellate cells (HSCs), and eventually suppresses HSC activation. J-1149 (20 μM) inhibits the expression of α-SMA and collagen I stimulated by TGF-β.
In Vivo: J-1149 (compound 15g) shows a good pharmacokinetic (PK) profile with a favorable half-life (t1/2 = 9.14 h).
相关产品：SB-431542 | Dorsomorphin | Adezmapimod | A 83-01 | SB 202190 | Afatinib | Galunisertib | LDN193189 | RepSox | Doramapimod | Aspirin | LY2109761 | DMH-1 | Oxidopamine hydrobromide | SB 525334 | BI-3406 | Butyzamide | Vactosertib | Ergothioneine | Hesperetin | Muramyl dipeptide | C16-PAF | BMP signaling agonist sb4 | SB-505124 | Ralimetinib dimesylate
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
J-1149,2883580-95-6
询价
