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文献和实验Imaging of Insulin Exocytosis from Pancreatic Beta Cells
The pancreatic beta cells are highly sensitive to the glucose concentration, and the minute to minute regulation of insulin secretion by glucose occurs at the level of exocytosis of insulin, transcriptional rate of the insulin gene
Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration
controversial. Postnatal islet regeneration may or may not depend on an influx of new islet cells from adult progenitors. To solve this issue in animal models, genetic lineage tracing has become a crucial research method. This method allows to test the various
Tissue-Specific Ablation of Tsc1 in Pancreatic Beta-Cells
anabolic cellular processes, such as translation, in response to growth factors and nutrient signals. In order to test roles for TSC1 and mTORC1 in β-cell function, we utilized Rip2 /Cre to generate mice lacking Tsc1 in pancreatic β cells (Rip-Tsc1 cKO mice
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