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文献和实验The Importance of Mouse ES Cell Line Selection
The choice of a specific parental ES cell line used to create a genetically modified mouse has critical impact on the overall success of the project – affecting costs, complexity of effort, and time to efficient project completion
strains. 1. Use C57BL/6 F1 mice to set up new breeding cages (see mouse breeding suggestions above). Most C57BL/6 F1 hybrids have good reproductive performance. We prefer (C57BL/6J X DBA/2J)F1 animals. Outbred CD-1 and ICR mice can be used
Mouse ES Cell-Derived Hematopoietic Progenitor Cells
before any clinical applications. The ability of these cells to engraft is dependent on their expression of cell surface markers which guide their homing patterns. In this review, I discuss murine hematopoietic progenitor cells derived from mouse ES cells. Stem cells
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