Sample:
Lane 1: Daudi cell lysates
Lane 2: PC-3 cell lysates
Lane 3: MCF-7 cell lysates
Lane 4: C6 cell lysates
Lane 5: L6 cell lysates
Lane 6: Rat brain tissue lysates
Primary: Anti-CREB3L4 (bsm-51569M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 21 kD
Observed band size: 40 kD
- ￥1180 - 1980
- Bioss
- bsm-51569M
- 2025年10月24日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 产品编号 | bsm-51569M |
| 英文名称 | CREB3L4 Mouse mAb |
| 中文名称 | CREB3L4单克隆抗体 |
| 英文别名 | cAMP responsive element binding protein 3 like 4; JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP; CR3L4_HUMAN; Cyclic AMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 3-like protein 4; Androgen-induced basic leucine zipper protein; Attaching to CRE-like 1; Cyclic AMP-responsive element-binding protein 4; CREB-4; cAMP-responsive element-binding protein 4; Transcript induced in spermiogenesis protein 40; Tisp40; Processed cyclic AMP-responsive element-binding protein 3-like protein 4. |
| 产品应用 | WB=1:500-1000 Not yet tested in other applications. |
| 交叉反应 | Human, Rat |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human CREB3L4 between 1-300 amino acids. |
| 亚型 | IgG1 |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 理论分子量 | 21 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper |
| 亚细胞定位 | Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. May also be located in Golgi apparatus. |
| 组织特异性 | According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. |
| 翻译后修饰 | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| 相似性 | Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain. |
| 功能 | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-1000} |
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CREB3L4 Mouse mAb(bsm-51569M)-50ul/100ul
￥1180 - 1980
