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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名:
Cynomolgus CD134 Protein, His Tag
- 库存:
999
- 供应商:
卡梅德生物科技(天津)有限公司
- 规格:
10ug/50ug
| 规格: | 10ug | 产品价格: | ¥1920.0 |
|---|---|---|---|
| 规格: | 50ug | 产品价格: | ¥5632.0 |
产品编号:KMP2387
产品名称:Cynomolgus CD134 Protein, His Tag
中文名称: Cynomolgus CD134 重组蛋白
中文全称:食蟹猴肿瘤坏死因子受体超家族成员4重组蛋白
产品描述:产品描述:The Cynomolgus CD134 Protein(KMP2387) is produced in HEK293 Cells and the target gene encoding Lys28-Ala214 is expressed with a 6His tag at the C-terminus.
产品别称:肿瘤坏死因子受体超家族成员4, Tumor necrosis factor receptor superfamily member 4, CD134
分子名称:CD134
预测分子量:20.81 kDa
物种:Cynomolgus
宿主:HEK293 Cells
规格:50ug, 100ug, 200ug
纯化方式:Affinity purification
纯度:>95% as determined by SDS-PAGE
内毒素水平:<1.0 EU/ug determined by the LAL method
缓冲体系:PBS, pH7.4
Uniport:A0A2K5TJH8
产品背景:OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand(OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
保存条件:Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件:In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明:This product is for research use only.
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文献和实验不只是 PD-1:CD96 正成为免疫治疗的下一个“必争之地”
2. CD96 的分子结构、表达特征与细胞分布 2.1 CD96 蛋白结构与分子特征 CD96 又称 Tactile,是一种跨膜糖蛋白,属于免疫球蛋白超家族成员。其分子结构提示其在细胞识别、黏附和信号转导中具有重要作用。已有研究尝试解析 CD96 作为免疫受体的结构基础 [4],但从目前研究情况来看,其与配体结合的精细结构机制仍有待进一步明确。 2.2 CD96 主要表达在哪些免疫细胞 CD96 具有明显的细胞类型特异性,其表达常受细胞活化状态及局部微环境调控。在 T 细胞中,CD96 是人类淋巴
,PD-1/PD-L1这么值钱,大家一定好奇它到底是什么鬼。 PD-1全名是程序性死亡分子1(programmed death-1)是Ishida等[1]通过消减杂交技术于1992年发现的[2],是CD28家族成员,胞质区含有2个酪氨酸残基,1个位于靠近N端的免疫受体酪氨酸抑制基序(ITIM)中,另一个1个位于靠近C端的免疫受体酪氨酸转化基序(ITSM)中[2]。 PD-L1(CD274)是B7家族成员,是PD-1的配体,属于1型跨膜蛋白,全长290个氨基酸,包含1个IgV样
域是在C型凝集素结构域和CCP结构域之间。 8.肿瘤坏死因子超家 (TNFSF) 为Ⅱ型膜分子,TNFSF结构域约由40个氨基酸残基组成。胞膜外区经蛋白酶水解脱落可形成可溶型、具有生物活性的分子,如TNF、LT和FasL。这个超家族大多数成员的分子可形成三聚体,同三聚体的相应膜受体结合。 9.肿瘤坏死因子受体超家 (TNFRSF)结构域 约由40个氨基酸残基组成,富含半胱氨酸。TNFRSF大多成员胞膜外区含有3或4个TNFRSF结构
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