重组人CD152蛋白|重组人细胞毒T淋巴细胞相关抗原蛋白

产品编号：KMP2303

产品名称：Human CD152 Protein, Fc Tag, Avi Tag

中文名称： 重组人CD152蛋白

中文全称：重组人细胞毒T淋巴细胞相关抗原蛋白

产品描述：产品描述：The Human CD152 Protein(KMP2303) is produced in HEK293 Cells and the target gene encoding Lys36-Asp161 is expressed with a Fc, Avi tag at the C-terminus.

产品别称：细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152

分子名称：CD152

预测分子量：13.5 kDa

物种：Human

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>95% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:P16410

功能：Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

产品背景：Cytotoxic T-lymphocyte protein 4, is a single-pass type I membrane protein. It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin(Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.

参考文献：1.Annu. Rev. Immunol. 24:65-97 (2006) 2.J. Exp. Med. 174:561-569 (1991)