Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Mouse CD152 Protein, His Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥640.0
规格:
50ug
产品价格:
¥1536.0
产品编号: KMP2299产品名称: Mouse CD152 Protein, His Tag中文名称: 鼠CD152蛋白中文全称: 鼠细胞毒T淋巴细胞相关抗原蛋白关键词: 细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4, Mouse CD152 Protein, His Tag, Recombinant Protein, KMP2299物种: Mouse宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: 20mM PB, 150mM NaCl, pH7.4Uniprot: P09793SDS-PAGE: KMP2299 SDS-PAGE image1.png功能: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.产品背景: Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. mouse CTLA4 cDNA encodes 223 amino acids(aa) including a 35 aa signal sequence, a 126 aa extracellular domain(ECD) with one Ig-like V-type domain, a 21 aa transmembrane(TM) sequence, and a 41 aa cytoplasmic sequence. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: