- ￥1120 - 3360
- 卡梅德/KMD Bioscience
- 天津
- KMP2269
- 2025年10月29日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名：
Mouse ILT3 Protein, Fc Tag
- 库存：
999
- 供应商：
卡梅德生物科技（天津）有限公司
- 规格：
10ug/50ug
| 规格： | 10ug | 产品价格： | ￥1120.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3360.0 |
产品编号：KMP2269
产品名称：Mouse ILT3 Protein, Fc Tag
中文名称： 重组鼠ILT3蛋白
中文全称：重组鼠白细胞免疫球蛋白样受体B亚家族成员4蛋白
产品描述：产品描述：The Mouse ILT3 Protein(KMP2269) is produced in HEK293 Cells and the target gene encoding Gly24-Lys238 is expressed with a Fc tag at the C-terminus.
产品别称：白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, ILT3
分子名称：ILT3
预测分子量：23.65 kDa
物种：Mouse
宿主：HEK293 Cells
规格：50ug, 100ug, 200ug
纯化方式：Affinity purification
纯度：>95% as determined by SDS-PAGE
内毒素水平：<1.0 EU/ug determined by the LAL method
缓冲体系：50mM Tris-HCl, 100mM Glycine, pH7.5
Uniport:Q64281
功能：Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169).产品背景：Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 is expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.
保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明：This product is for research use only.
参考文献：1.J. Biol. Chem. 274:5791-5796 (1999) 2.Nat. Immunol. 2:436-442 (2001) 3.J. Exp. Med. 194:227-234 (2001) 4.J. Immunol. 170:4095-4101 (2003) 5.Eur. J. Immunol. 33:2262-2268 (2003) 6.J. Immunol. 193:635-644 (2014) 7.Int. Immunol. 33:447-458 (2021) 8.J. Immunol. 158:9-12 (1997)
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