Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
英文名:
Human ILT3 Protein, Fc Tag
库存:
999
供应商:
卡梅德生物科技(天津)有限公司
规格:
10ug/50ug
规格:
10ug
产品价格:
¥1680.0
规格:
50ug
产品价格:
¥5040.0
产品编号: KMP2278产品名称: Human ILT3 Protein, Fc Tag中文名称: 重组人 ILT3蛋白中文全称: 重组人白细胞免疫球蛋白样受体 B 亚家族成员 4蛋白关键词: 白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, Mast cell surface glycoprotein Gp49B, CD85k, Lilrb4, Gp49b, Human ILT3 Protein, Fc Tag, Recombinant Protein, KMP2278物种: Human宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >90% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: PBS, pH7.4Uniprot: Q8NHJ6SDS-PAGE: KMP2278 SDS-PAGE image1.png功能: Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462).Receptor for FN1 (PubMed:34089617).Receptor for apolipoprotein APOE (PubMed:30333625).Receptor for ALCAM/CD166 (PubMed:29263213).Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699).Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736).This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617).Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213).Induces up-regulation of CD86 on dendritic cells (PubMed:19860908).Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462).Activated by APOE on acute myeloid leukemia (AML) cells which leads to suppression of T cell proliferation and promotion of AML cell migration and infiltration (PubMed:30333625).LILRB4 signaling on AML cells is mediated by PTPN11/SHP-2 (PubMed:30333625).产品背景: Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 is expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: 1.Nat. Immunol. 3:237-243 (2002)2.J. Immunol. 176:2790-2798 (2006)3.J. Biol. Chem. 284:34839-34848 (2009)4.BMC Immunol. 10:56-56 (2009)5.J. Immunol. 200:1207-1219 (2018)6.Nature 562:605-609 (2018)7.Int. Immunol. 33:447-458 (2021)8.J. Exp. Med. 185:1743-1751 (1997)