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文献和实验人白细胞抗原(human leukocyte antigen,HLA)
gene)。人的定位MHC在第6号染色体上,小鼠的则定位在第17号染色体上。 组织相容性抗原按其免疫性能可分为三类:第一类是移植抗原(transplanta—tion antigen),负责排斥外来的组织,存在于杀伤性T淋巴细胞(killer T leukocyte)中,为细胞介导的免疫反应所必需,小鼠的I类基因编码H2-K和H2-D/L蛋白质,人的I类基因编码移植抗原HLA-A,B,C;第二类是参与免疫反应过程中细胞之间的信息传递,人的Ⅱ类区称为HLA-D,又可分为4个亚区,排列顺序为DR,DQ
Molecular Typing of the MHC Class I Chain-Related Gene Locus
The human major histocompatibility complex (MHC) class I chain-related genes A and B (MICA and MICB ) are located within the human leukocyte antigen (HLA) class I region of chromosome 6 (1 ). Their organization, expression, and products
Major histocompatibility complex (MHC) class I human genes have been divided into two different subgroups. The classical class I loci, human leukocyte antigen (HLA)-A, -B and -C, encode highly polymorphic membrane glycoproteins
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