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- 2025年07月10日
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文献和实验Adenovirus (Ad) vectors have been used to successfully deliver genes into a wide variety of non-central nervous system (CNS) tissues and organs in animal models of human disease and in several human phase I clinical trials (1 –
Gene Transfer to Articular Chondrocytes with Recombinant Adenovirus
in chondrocytes, including the bone morphogenic proteins (BMPs), transforming growth factor-βs (TGF-βs) and insulinlike growth factors (IGFs). Improved repair has been reported following in vivo administration of recombinant IGF-1 (1 ) or BMP-2 (2 ) to cartilage
Local Gene Delivery of Recombinant Adenoviruses to the Rat Carotid Artery In Vivo
A number of animal models are available to investigators wishing to study the use of gene transfer to prevent neointimal formation after vascular injury. The majority are models of primary vascular injury rather than the human situation
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