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文献和实验Collagen-Induced Arthritis in Mice: A Major Role for Tumor Necrosis Factor-
arthritis, including tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, IL-6, IL-1Ra, IL-10, and transforming growth factor β. The use transgenic and knockout strains of mice, as well as biological inhibitors, have revealed important pathological roles
The TNF superfamily member TWEAK has emerged as a pleiotropic cytokine that regulates many cellular functions that include immune/inflammatory activity, angiogenesis, cell proliferation, and fate. TWEAK through its inducible receptor, FGF
TRAF‐Mediated TNFR‐Family Signaling
Figure 11.9.1 Domain organization of mammalian tumor‐necrosis factor receptor (TNFR)‐associated factors (TRAFs). The TRAF family consists of seven proteins. Each TRAF, except TRAF1, has a RING‐finger domain
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