Animal-Free Human LIF (5ug)

LiF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma, Llf promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation, Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While humaniF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LlF is not active on human cells due to its inability to bind to the human LIF receptor.