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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
储存于-20 ° C
- 保质期：
1年
- 英文名：
Topotecan
- 库存：
100
- 供应商：
艾美捷科技
- CAS号：
无
- 规格：
10mM (in 1mL DMSO)
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文献和实验Purification of DNA Topoisomerase I from Human Placenta
DNA topoisomerase I (topo I) has been firmly established as the molecular target of the camptothecin group of anticancer drugs. These drugs include camptothecin, topotecan, 9-amino-camptothecin, and irinotecan
Cytometric Assessment of DNA Damage Induced by DNA Topoisomerase Inhibitors
with the cell cycle phase or DNA ploidy. The protocol can also be used to assess activation (Ser- 1981 phosphorylation) of ATM; this event also revealing DNA damage induced by topo I or topo II inhibitors. Examples where DNA damage was induced by topotecan (topo
Detection of DNA Strand Breaks in Apoptotic Cells by Flow- and Image-Cytometry
one to correlate the induction of apoptosis with the cell cycle phase. Examples of the detection of apoptotic cells in cultures of human leukemic cell lines treated with TNF-α and DNA topoisomerase I inhibitor topotecan are presented. The protocol can be applied
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