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- 详细信息
- 文献和实验
- 技术资料
- 英文名:
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- 库存:
现货库存
- 供应商:
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- 肿瘤类型:
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- 细胞类型:
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- 品系:
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- 组织来源:
ATCC/DSMZ/ECACC
- 相关疾病:
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- 物种来源:
人或动物
- 免疫类型:
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- 细胞形态:
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- 是否是肿瘤细胞:
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- 器官来源:
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- 运输方式:
常温或干冰
- 年限:
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- 生长状态:
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- 规格:
T25
| 种属 | 小鼠 |
| 组织来源 | 正常肺组织 |
| 传代比例 | 1:2传代 |
| 完全培养基配置 | 基础培养基500ml ;生长添加剂5ml ;胎牛血清50ml ;双抗5ml |
| 简介 | 肺巨噬细胞由单核细胞分化而来 ,广泛分布在肺间质内 ,在细支气管以下的管道周围和肺泡隔内较多。肺巨噬细胞的 吞噬、免疫和分泌作用都十分活跃 ,有重要防御功能。吸入空气中的尘粒、细菌等异物进入肺泡和肺间质 ,多被巨噬 细胞吞噬清除 ,故细胞胞质内常见尘粒、细菌等物进入肺泡和肺间质 ,多被巨噬细胞吞噬清除 ,故细胞胞质内常见尘 粒、次级溶酶体及吞噬体等 ,肺巨噬细胞还可吞噬衰老的红细胞 ,在心力衰竭患者出现肺瘀血时 ,大量红细胞从毛细 血管溢出 ,被巨噬细胞吞噬。吞噬异物的巨噬细胞 ,有的从肺泡腔经呼吸道粘液流动和纤毛运动而被咳出 ,有的进入 肺淋巴管随淋巴进入肺淋巴结内。 |
osteoimmuno-oncology (OIO), which refers to interactions between bone, immune and tumor cells in bone metastatic microenvironment. We also discuss therapeutic opportunities of targeting immune cells in bone metastases, and associated eff icacy and safety concerns.Although their therapeutic ewdtcacy remains unsatisfying in patients with cancer. Here, we design a photodynamic therapy (PDT)-motivated ATV (P-ATV) in Fmoc-KCRGDK-phenylboronic acid (FK-PBA) hydrogel, which mobilizes local immune activation to inhibit relapse of postoperative
Questions/purposes: Our objectives were (I) characterize the epidemiology of de novo bone metastasis with respect to patient demographics, (II) characterize the incidence by primary site, age, and sex (2010-2015), and (III) compare survival of de novo metastatic cancer patients with and without bone metastasis.
Methods: This is a retrospective, population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results program, 2010-2015. Incidence rates by year of diagnosis, annual percentage changes, Kaplan-Meier, univariate and multiple Cox regression models are included in the analysis.
Results: Of patients with cancer in the SEER database, 5.1% were diagnosed with metastasis to bone, equaling ~18.8 per 100,000 bone metastasis diagnoses in the US per year (2010-2015). For adults >25, lung cancer is the most common primary site (2015 rate: 8.7 per 100,000) with de novo bone metastases, then prostate and breast primaries (2015 rates: 3.19 and 2.38 per 100,000, respectively). For patients <20 years old, endocrine cancers and soft tissue sarcomas are the most common primaries. Incidence is increasing for prostate (Annual Percentage Change (APC) = 4.6%, P < 0.001) and stomach (APC = 5.0%, P = 0.001) cancers. The presence of de novo bone metastasis was associated with a limited reduction in overall survival (HR = 1.02, 95%, CI = [1.01-1.03], p < 0.001) when compared to patients with other non-bone metastases.
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文献和实验/immunotherapy continues to demonstrate ef ficacy in a variety of refractory cancers, currently, no any immunotherapeutic strategy is clinically used for gastric cancer (GC) except its microsatellite instable subtype. Thus, it is important to identify molecular biomarkers for predicting the
免疫活性细胞之一。几乎遍布于动物体内一切组织,对颗粒状异物和体内衰老细胞等进行捕食、消化的大型变形虫样细胞之总称。血单核细胞( bloodmonocyte),肺泡巨噬细胞( alveolar macropha-ge),腹腔巨噬细胞( peritoneal macrophage),炎症肉芽肿巨噬细胞( inflammatory granuloma ma-crophage)等是游离巨噬细胞( free macrophage)。与此相反,枯否氏星形细胞( von Kupffer’ s cell
Cell I 乳腺癌良好预后的新型生物标志物— FOLR2+巨噬细胞
当前乳腺癌的发病率居所有女性恶性肿瘤首位,根据世界卫生组织国际癌症研究机构(简称 IARC )发布的《2021 年全球最新癌症负担》数据,全球乳腺癌新增人数达 265 万,已超越肺癌成为“全球第一大癌症”。目前乳腺癌的主要治疗方式有手术治疗、化学药物治疗、放射治疗、内分泌治疗及靶向治疗等,然而这些治疗手段并不能让所有患者都能有效获益,因而创新药物的研发与上市对于提高乳腺癌患者生存期,改变乳腺癌治疗格局具有深远意义。 肿瘤相关巨噬细胞(tumor-associated macrophage
标题:小鼠肺泡灌洗标准操作规程关键词: 肺泡灌洗;细胞分类计数;细胞因子目的:检查小鼠各种病理生理状态(特别是肺部疾病)下,肺部出现的各种病理改变。例:哮喘模型中检测嗜酸细胞的分类数有否提高,灌洗液中各种细胞因子,如IL-4,IL-5,IL-10,IFN-r等水平。主体内容(操作步骤):实验的准备实验的器材、仪器、药品:4℃遇冷的单纯PBS和4℃遇冷的含1%BSA的PBS;手术器械:眼科剪,眼科镊,穿刺针或4号半头皮针;血细胞计数板;低温离心机实验操作规程:灌洗分单侧和双侧。单侧一般为颈部
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