] FigueroaEG,González-CandiaA,Caballero- RománA,etal.Blood - brainbarrierdysfunctioninhemorrhagictransformation:atherapeutic opportunityfornanoparticlesandmelatonin[J].JNeurophysiol,2021,125( 6):2025-2033.tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells, have been shown to support tumor growth in addition to invasion and wtrastasis. Each step of tumor development, from initiation through wtrastatic spread, is promoted by communication between