0.18)ng/mL],thedifferences werestatisticallysignificant( P <0.05).Thelevelsof serumHMGB-1andsRAGEwerethehighestinpatientswithseverebasalgangliaintrac-erebralhemorrhage,followedbymediumandmildpatients;therewere81 casesinthegoodprognosisgroupand57 casesinthepoorprognosis group,thelevelsofserumHMGB-1andsRAGEinthepoorprognosisgroupwere( 7.98± 1.31) mg influences cancer progression via multiple mechanisms, including the tumor immune response, with thrombin emerging as a target for novel therapeutic strategies for cancer.Tumour