WÓJCIK-PSZCZOŁAK, CHŁOÑ-RZEPAG,JANKO WSKA A,etal. A novel,pan-PDE inhibitorexerts anti-fibroticeffectsinhumanlungfibroblastsviainhibitionof TGF-βsignalingandactivationofcAMP/PKA signaling[J]. IntJMolSci,2020,21(11) :4008-4030.immune evasion by developing tumors is endorsed by its inclusion as one of the (updated) hallmarks of cancer. A greater understanding of this dimension can potentially lead to novel applications of existing standard of care therapies, in addition to potentiating their effect. This review summarizes the immune aspects of currently employed therapies-cytotoxic