19156044901 (同微信) maltransition(EMT)⁃associatedproteins. Results:ElevatedEMT andfibrosisphenotypewasfoundinHPFssignificantlyascomparedwiththatofhumanconjunctivafibroblasts. MiRNA⁃199a⁃3p/5pmimic down⁃regulated DUSP5/MAP3K11,and promoted HPFs' fibrosisandEMT, whilemiR⁃199a⁃modulation to improve the antitumor immune response and the efficacy of immunotherapy.Immunotherapy has become one of the most attraction cancer therapy strategies. The PD-1/PD-L1 pathway plays key roles in immune responses and autoimmunity by