The dry and fresh weight ofmaize alsoshowedasignificant(P< 0.05)increase of 37.67 % and 40.6 %, respectively(Fig. S2).In brief,biocharcombined with E. cloacae and DCD appearedtobeaneffectivestrategyforimproving theNUE. managementandapplicationpracticeshaveledtoarangeofecologicalandenvironmental problems that seriously threaten food security. In this study, an N fertilizer managementstrategywasestablishedforimproving This paper also describes past clinical trials of immunotherapy for patients with GC and details their clinical implications. Strong predictive markers are essential to improve response to immunotherapy.to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to strategy that targets MYC can initiate a new era of cancer treatment. In this review, we summarize the essential role of the MYC signaling pathway in tumor immunity and the