Cl-4AS-1,188589-66-4

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Cl-4AS-1

CAS No. : 188589-66-4

MCE 国际站：Cl-4AS-1

产品活性：Cl-4AS-1 是一种有效的类固醇雄激素受体 (AR) 激动剂 (IC₅₀ 为 12 nM)，也是 5α- 还原酶 I 型和 II 型的抑制剂 (IC₅₀ 分别为 6 和 10 nM)。

研究领域：Vitamin D Related/Nuclear Receptor

作用靶点：Androgen Receptor

In Vitro: Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells.
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%.

In Vivo: Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight.

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