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TZ4M
MCE 国际站：TZ4M
产品活性：TZ4M 是一种基于 2,4-噻唑烷二酮 (TZD) 的抗阿紫海默症试剂，具有神经保护作用。TZ4M 在人血浆中表现出 AChE 抑制作用。TZ4M 在东莨菪碱 (HY-N0296) 诱导的阿尔茨海默型模型中改善成年大鼠记忆和认知障碍。
研究领域：Neuronal Signaling
作用靶点：Cholinesterase (ChE)
In Vivo: In rat model, TZ4M (2 and 3 mg/kg; ip; once daily for 8 days) inhibits Scopolamine (3 mg/kg; ip) induced neuronal damage in the hippocampus and apoptosis of hippocampus neurons and cortexin, and expands the number of mAChR M1 in neurons of the DG region and CA1 of the hippocampus and cortex.
TZ4M is encountered to be BBB positive via CBligand-BBB forecast, which is needed for AChE inhibition.
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文献和实验说起基因组序列数据库，大多数人耳熟能详的是三巨头GenBankEBIDDBJ这些数据库在设计之初虽然考虑了基因组存储的需求，但在基因组分析和数据挖掘上的功能设计则比较欠缺。而 IMG/M 作为新一代基因组数据库的代表，不仅能够完整收录现有数据库的内容，还提供了更完善的数据上传、注释和分析服务，将测序数据储存到 IMG/M 数据库（即将 IMG/M 数据库的登录号填写到文章中）也是被许多顶尖期刊如 Nature Communication 所接受的。IMG/M 数据库接受上传纯培养测序基因
Oocyte Extracts for the Study of Meiotic M-M Transition
In meiotic cell cycles, meiosis I (MI) is followed by meiosis II (Mil) without an intervening S phase, whereas in mitotic cell cycles, an S phase necessarily alternates with an M phase. For the study of mitotic cell cycles, extracts prepared
The Use of M-FISH and M-BAND to Define Chromosome Abnormalities
Multicolour fluorescence in situ hybridisation (M-FISH) and multicolour banding (M-BAND) are advanced chromosome painting techniques combining multiple chromosome- or region-specific paints in one step. M-FISH identifies all chromosomes
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