IP2,2247640-44-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IP2

CAS No. :

MCE 国际站：IP2

产品活性：IP2 是一种免疫调节剂。IP2 增加癌细胞中 PTP 衍生的抗原呈递。IP2 对癌细胞无细胞毒性。IP2 在小鼠体内诱导肿瘤生长缺陷。

研究领域：Others

作用靶点：Others

In Vitro: IP2 (35 µM) shows immunomodulatory activity in murine MCA205 fibrosarcoma cells.
IP2 (35 µM) increases in the intron-derived SL8 antigen presentation.
IP2 (10 µM; 72 h) shows non-cytotoxic for cancer cells.
IP2 (10 µM) shows selectivity against three G-protein coupled receptor ADRB1 (35%), HRH2 (40%), and OPRD1 (53%), and inhibits the three enzymes of COX1 (52.8%), PDE3A (84.8%), and PDE4D2 (87.2%).
IP2 (10 µM) dose not induce immunogenic cell death hallmarks in human osteosarcoma U2OS cells.

In Vivo: IP2 (0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog) shows a high bioavailability in mice.
IP2 (50, 100, 250, 500 mg/kg; i.p.) shows very well toleration in C57BL/6 mice.
IP2 (2.5 mg/kg; i.v.) induces tumor growth defects in C57BL/6 mice.
IP2 (5 mg/kg; intratumor injection; three times per week for 2 weeks) induces tumor growth defects in C57BL/6 mice.
Pharmacokinetic Parameters of IP2 in Male C57BL/6J mice and male beagle dog.

	Dose (mg/kg)	Cmax (ng/mL)	Tmax (h)	T1/2 (h)	CL (mL/min/kg)	F %	MRT0-t (h)	AUCtot (ng/mL·h)	AUCextra (%)
ip mice	9.103	2078	0.0833	0.8	154	86	0.7	982.3	1.3
iv mice	0.711	322.7	0.0833	1.1	133		0.9	88.8	15.2
iv dog	26.76	272 (µg/mL)	0.0833	3.8	0.69		3.8	654.7 (µg/mL·h)	0.9

Male C57BL/6J mice and male beagle dog; 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for mice; 26.76 mg/kg for i.v. for dog.

相关产品：Digitonin  |  5-Ph-IAA  |  FLAG peptide  |  Tocofersolan  |  Monocrotaline  |  Lactate sodium  |  TCEP hydrochloride  |  3X FLAG peptide  |  DPPH  |  Pertussis Toxin  |  Pronase E (Activity ≥ 7000 U/g)  |  O-Propargyl-Puromycin  |  NMDI14  |  Phytohemagglutinin  |  MYLS22  |  Hyaluronidase  |  Biotinyl tyramide  |  Kifunensine  |  Human IgG1 kappa, Isotype Control  |  4-Azido-L-phenylalanine  |  6-Aminonicotinamide  |  Ammonium tetrathiomolybdate(VI)  |  OVA Peptide(257-264) TFA  |  Alkyne-phenol  |  Lauryl maltose neopentyl glycol  |  SHIN1  |  CHAPS  |  Cytosporone B

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds