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Lipid-lowering agent-1
CAS No. : 2304859-34-3
MCE 国际站：Lipid-lowering agent-1
产品活性：Lipid-lowering agent-1 是一种有效的降脂剂。Lipid-lowering agent-1 具有显著的抑制低密度脂蛋白胆固醇 (LDLC) 和促进高密度脂蛋白胆固醇 (HDLC) 产生的药理作用。Lipid-lowering agent-1 对高脂饮食大鼠有显著的降脂作用。
研究领域：Others
作用靶点：Others
In Vitro: Lipid-lowering agent-1 (compound 1m) (12.5 μM; 72 hours) does not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration.
Lipid-lowering agent-1 (10 μM; 24 hours) has significant pharmacological effects on the inhibition of LDLC and promotion of HDLC production.
Lipid-lowering agent-1 (10 μM; 24 hours) inhibits the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%.
Lipid-lowering agent-1 (10 μM; 10 days) decreases yellow lipid droplets effectively in 3T3-L1 cells.
In Vivo: Lipid-lowering agent-1 (15 mg/kg; i.g., daily for 40 or 80 days) reduces blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes is still better than that of berberine after dosing 80 days.
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文献和实验PROCEDURE 1. Resuspend tissue/extract in 5 volumes of 1:1 chloroform/methanol by vortexing (to homogeneity or as close as possible) 2. Add the same volume of a 1M KCl, 0.2M Phosphoric acid
脂质 A lipid A 以葡萄糖胺、磷酸、脂肪酸为主要成分的糖脂质，是内毒素的活性中心部分。
PROCEDURE 1. Resuspend tissue/extract in 5 volumes of 1:1 chloroform/methanol by vortexing (to homogeneity or as close as possible) 2. Add the same volume of a 1M KCl, 0.2M Phosphoric acid solution and vortex again 3. Centrifuge sample at 10
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