Antibacterial agent 166

价格询价

品牌MedChemExpress(MCE)
产地美国
货号HY-155491
更新日期2025年12月05日

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Antibacterial agent 166

CAS No. :

MCE 国际站：Antibacterial agent 166

产品活性：Antibacterial agent 166 是 Nitishinone (HY-B0607) 的衍生物，是一种具有选择性和口服活性的Fusobacterium nucleatum 抑制剂，MIC₅₀ 为 1 μg/mL。Antibacterial agent 166 有效地减弱由 Fusobacterium nucleatum 诱导的 MC-38 细胞的迁移能力。Antibacterial agent 166 是一种有前途的抗核粒梭杆菌 (anti-F. nucleatum) 先导化合物，可用于结直肠癌（CRC）研究。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Antibacterial agent 166 (Compound 19q) (1-4 μg/mL, 0-72 h) inhibits the growth and biofilm formation of Fusobacterium nucleatum in a dose dependent manner.
Antibacterial agent 166 (1-4 μg/mL, 4-48 h) inhibits the growth of Fusobacterium nucleatum by downregulating the expression of NTR.
Antibacterial agent 166 (1-4 μg/mL, 48 h) downregulates the expression of the tnaA gene in the late-log-phase in a dose-dependent manner.
Antibacterial agent 166 (2-4 μg/mL, 48 h) possesses stronger migratory inhibition potency against MC-38 under the stimulation of Fusobacterium nucleatum.
Antibacterial agent 166 exhibits the most potent inhibitory activity against MC-38 cells, with an IC₅₀ of 11 μM.
Antibacterial agent 166, exhibits moderate to weak antiproliferative activity two human normal cell lines with an IC₅₀ of 16 μM, possess low cytotoxicity.

In Vivo: Antibacterial agent 166 (Compound 19q) (1500 mg/kg, single dose) has little toxic side effects on the organs.
Antibacterial agent 166 (20 mg/kg, p.o, single dose) can inhibit Fusobacterium nucleatum locally in the intestinal tract and has lower systemic toxicity.
Antibacterial agent 166 (1 mg/kg, Intravenous injection) half-life is approximately 0.068 h, the peak concentration C_max and plasma clearance (CL) were 85 ng/mL and 36054 mL/h/mg.