LSD1-IN-13,2170347-90-5

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LSD1-IN-13 hydrochloride

CAS No. : 2170347-90-5

MCE 国际站：LSD1-IN-13 hydrochloride

产品活性：LSD1-IN-13 hydrochloride (compound 7e) 是一种口服有效的 LSD1 抑制剂，其 IC₅₀ 值为 24.43 nM。LSD1-IN-13 hydrochloride 可激活 CD86 表达，其 EC₅₀ 值为 470 nM。LSD1-IN-13 hydrochloride 诱导 AML (急性髓系白血病)细胞系分化。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold).
LSD1-IN-13 hydrochloride shows potent and selective antiproliferative activity in MV-4-11, with an IC₅₀ of 1.36 μM.

In Vivo: LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner.

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