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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
齐源
- 库存:
868
- 靶点:
CD11c
- 级别:
CD11c (Maxpar® Ready) Antibody
- 目录编号:
CD11c (Maxpar® Ready) Antibody
- 克隆性:
单克隆
- 抗原来源:
小鼠
- 保质期:
CD11c (Maxpar® Ready) Antibody
- 抗体英文名:
Purified anti-human CD11c (Maxpar® Ready) Antibody
- 抗体名:
CD11c (Maxpar® Ready) Antibody
- 标记物:
CD11c (Maxpar® Ready) Antibody
- 宿主:
小鼠
- 适应物种:
人、猴
- 免疫原:
CD11c (Maxpar® Ready) Antibody
- 亚型:
CD11c (Maxpar® Ready) Antibody
- 形态:
CD11c (Maxpar® Ready) Antibody
- 应用范围:
FC, CyTOF®
- 保存条件:
2-8℃
- 浓度:
1.0 mg/ml
- 规格:
100 µg
Description :CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin α and CR4.CD11c non-covalently associates with integrin β2 (CD18) and is expressed onmonocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells.CD11c has been reported to play a role in adhesion and CTL killing through its interactionswith fibrinogen, CD54, and iC3b.
Verified Reactivity :Human, Cynomolgus, Rhesus
Reported Reactivity :African Green, Baboon, Chimpanzee, Squirrel Monkey
Antibody Type :Monoclonal
Host Species :Mouse
Formulation :Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
Preparation :The antibody was purified by affinity chromatography.
Concentration :1.0 mg/ml
Storage & Handling :The antibody solution should be stored undiluted between 2°C and 8°C.
Application :FC - Quality tested、CyTOF® - Verified
Recommended Usage :This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling usingMaxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue withthe protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar®Ready antibodies.
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文献和实验1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
2. Knapp W, et al. 1989. Leucocyte Typing IV Oxford University Press. New York.
3. McMichael A, et al. Eds. 1987. Leucocyte Typing III Oxford University Press. New York.
4. Vainer B, et al. 2000. Am. J. Surg. Pathol. 24:1115. (IHC)
5. Ottonello L, et al. 1999. Blood 93:3505.
6. Metelitsa LS, et al. 2002. Blood 99:4166.
7. Sadhu C, et al. 2007. J. Leukoc. Biol. doi:10.1189/jlb.1106680. PubMed
8. Ihanus E, et al. 2007. Blood 109:802-810.
9. Gurer C, et al. 2008. Blood 112:1231. PubMed
10. Asai A, et al. 2009. J. Lipid Res. 50:95. PubMed
11. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
12. Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42. (FC)
Product Citations:
1. Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
该药)5、我国单克隆抗体药物研发进展情况近年来中国的单抗技术已经受到越来越多的关注和重视,单克隆抗体药物研究已被列入863计划和国家重点攻关项目。目前,中国已有2个治疗性单抗产品获准生产,3个治疗性产品处在临床试验阶段,多个抗体药物处于临床前研究阶段,已批准的诊断性单抗有31个。武汉生物制品研究所抗肾移植单抗OKT3(注射用鼠源性抗人T淋巴细胞CD3抗原单克隆抗体)最早批准上市,具有免疫抑制作用,可逆转对移植器官的排斥反应。东莞宏远逸士生物技术药业开发的生物制品国家一类新药:粤宏远(0573)下属
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-down模式(即间接法)联合抗人检测抗体进行分析,因此不受影响。相比之下,SARS-CoV-2抗原的免疫分析通常使用夹心法模式,容易受到干扰性抗体的影响。 判定干扰性抗体是否是导致错误结果的原因,可以使用市面上商业化的ELISA试剂盒进行检测,这些试剂盒设计用于鉴别嗜异性抗体、HAMA和RF(通常简称为HAMA-ELISA)。鉴定后,常使用HAMA阻断剂来解决干扰问题。该解决方案的缺点是更多的生物活性成分-抗体-被添加到分析中,这可能会导致新的干扰。一般情况,多数生产商会提供几种不同的HAMA阻断











