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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
齐源
- 库存：
986
- 靶点：
CD194 (CCR4)
- 级别：
CD194 (CCR4) Antibody
- 目录编号：
CD194 (CCR4) Antibody
- 克隆性：
单克隆
- 抗原来源：
亚美尼亚仓鼠
- 保质期：
CD194 (CCR4) Antibody
- 抗体英文名：
Biotin anti-mouse CD194 (CCR4) Antibody
- 抗体名：
CD194 (CCR4) Antibody
- 标记物：
CD194 (CCR4) Antibody
- 宿主：
亚美尼亚仓鼠
- 适应物种：
小鼠
- 免疫原：
CD194 (CCR4) Antibody
- 亚型：
CD194 (CCR4) Antibody
- 形态：
CD194 (CCR4) Antibody
- 应用范围：
FC
- 保存条件：
2-8℃
- 浓度：
0.5 mg/ml
- 规格：
25 ug/100 ug
| 规格： | 25 ug | 产品价格： | ￥2100.0 |
|---|---|---|---|
| 规格： | 100 ug | 产品价格： | ￥4500.0 |
Biotin anti-mouse CD194 (CCR4) Antibody详细如下：
Description ：Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85%identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naïve T cells,bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes andexpress cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity tomigrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play animportant role in the ligand-mediated recruitment of T cells into the skin in mice and humans,specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site ofinjury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucialfor the induction and maintenance of self-tolerance and are present in peripheral tissues suchas skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ Tregulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor andits ligand CCL22 (5).
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation ：The antibody was purified by affinity chromatography and conjugated with biotin under optimalconditions.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
Description ：Mouse CCR4 cDNA contains 1531 bp, and encodes a protein of 360 amino acids that is 85%identical to human CCR4. CCR4 binds CCL17 (TARG) and CCL22 (MDC). Naïve T cells,bearing receptors for cutaneous antigens, become activated in skin-draining lymph nodes andexpress cutaneous lymphocyte antigen (CLA), which confers to these cells the capacity tomigrate into the skin to exert their normal effector functions (1). CCR4 and CCR10 play animportant role in the ligand-mediated recruitment of T cells into the skin in mice and humans,specifically with regards to tethering, firm adhesion, and subsequent extravasation to the site ofinjury (2,3). CCR4 is expressed in cutaneous regulatory T cells (Tregs). These cells are crucialfor the induction and maintenance of self-tolerance and are present in peripheral tissues suchas skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ Tregulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor andits ligand CCL22 (5).
Verified Reactivity ：Mouse
Antibody Type ：Monoclonal
Host Species ：Armenian Hamster
Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation ：The antibody was purified by affinity chromatography and conjugated with biotin under optimalconditions.
Concentration ：0.5 mg/ml
Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application ：FC - Quality tested
Recommended Usage ：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometricanalysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cellsin 100 µl volume. It is recommended that the reagent be titrated for optimal performance for eachapplication.
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文献和实验该产品被引用文献
Application References(PubMed link indicatesBioLegend citation)：
1. Saito K, et al. 2008. J. Immunol. 181:6889. PubMed
2. Ueha S, et al. 2007. J. Leukoc. Biol. 82:1230. PubMed
3. Sharma R, et al. 2009 J. Immunol. 183:1065 (FC) PubMed
4. Dogan R, et al. 2011. J. Leukoc. Biol. 89:93. PubMed
5. Liu H, et al. 2011. Sci Transl Med. 3:82. PubMed.
6. Shankar SP, et al. 2012. J Immunol. 188:6347. PubMed.
Product Citations：
1. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
1. Saito K, et al. 2008. J. Immunol. 181:6889. PubMed
2. Ueha S, et al. 2007. J. Leukoc. Biol. 82:1230. PubMed
3. Sharma R, et al. 2009 J. Immunol. 183:1065 (FC) PubMed
4. Dogan R, et al. 2011. J. Leukoc. Biol. 89:93. PubMed
5. Liu H, et al. 2011. Sci Transl Med. 3:82. PubMed.
6. Shankar SP, et al. 2012. J Immunol. 188:6347. PubMed.
Product Citations：
1. Cowan J, et al. 2014. J Immunol. 193:1204. PubMed
文献支持
生物素 抗小鼠 CD194 (CCR4) 抗体
￥2100 - 4500
