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Vacara cat#10020 Native Carti
lage Oligomeric Matrix Protein, recombinant human (rhCOMP)- ￥3000
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- 文献和实验
- 技术资料
- 库存：
1
- 英文名：
Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)
- 保质期：
1年
- 供应商：
北京博蕾德生物科技有限公司
- 保存条件：
-20℃
- 规格：
100ug
Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis in the C57BL/6 Mouse - The Methodology
Genetically modified mouse strains have most often been developed on the C57BL/6 genetic background, which has restricted their use for rheumatology research due to the lack of reliable model for rheumatoid arthritis (RA) for this strain. The C57BL/6 mice possess the MHC class II haplotype H‑2b, which has so far prohibited induction of any known model for rheumatoid arthritis.
Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis is a new model for rheumatoid arthritis in the C57BL/6 mouse. It is established by immunization by native COMP and leads to severe arthritis with characteristic T and B cell responses against defined COMP peptides.
COMP induced arthritis provides disease model to study the immune priming, the effector and chronic phases of arthritis and can be used for efficient induction of arthritis in the C57BL/6J mice.
The key for successful arthritis experiments to solve your research questions is a thorough understanding of the model with its advantages and limitations.
Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis is a new model for rheumatoid arthritis in the C57BL/6 mouse. It is established by immunization by native COMP and leads to severe arthritis with characteristic T and B cell responses against defined COMP peptides.
COMP induced arthritis provides disease model to study the immune priming, the effector and chronic phases of arthritis and can be used for efficient induction of arthritis in the C57BL/6J mice.
The key for successful arthritis experiments to solve your research questions is a thorough understanding of the model with its advantages and limitations.
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文献和实验该产品被引用文献
1. Holmdahl R, Andersson M, Goldschmidt TJ, Gustafsson K, Jansson L, Mo JA. Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990;118:193-232.
2. Bäcklund J, Li C, Jansson E, Carlsen S, Merky P, Nandakumar KS, et al. C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann Rheum Dis. 2013;72(7):1225-32.
3. Zhao Y, Urbonaviciute V, Xu B, Cai W, Sener Z, Ge C, et al. Cartilage Oligomeric Matrix Protein Induced Arthritis-A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse. Front Immunol. 2021;12:631249.
4. Holmdahl R, Carlsen S, Mikulowska A, Vestberg M, Brunsberg U, Hansson A-S, et al. Genetic analysis of murine models for rheumatoid arthritis. In: Adolpho KW, editor. Human Genome Methods. New York: CRC press; 1998. p. 215-38.
5. Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012;14(4):R191.
6. Malmström V, Michaëlsson E, Burkhardt H, Mattsson R, Vuorio E, Holmdahl R. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis. Proc Natl Acad Sci U S A. 1996;93(9):4480-5.
7. Hultqvist M, Bäcklund J, Bauer K, Gelderman KA, Holmdahl R. Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice. J Immunol. 2007;179(3):1431-7.
8. Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, et al. Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum. 2008;58(7):2000-11.
9. Carlsén S, Hansson AS, Olsson H, Heinegård D, Holmdahl R. Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin Exp Immunol. 1998;114(3):477-84.
2. Bäcklund J, Li C, Jansson E, Carlsen S, Merky P, Nandakumar KS, et al. C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann Rheum Dis. 2013;72(7):1225-32.
3. Zhao Y, Urbonaviciute V, Xu B, Cai W, Sener Z, Ge C, et al. Cartilage Oligomeric Matrix Protein Induced Arthritis-A New Model for Rheumatoid Arthritis in the C57BL/6 Mouse. Front Immunol. 2021;12:631249.
4. Holmdahl R, Carlsen S, Mikulowska A, Vestberg M, Brunsberg U, Hansson A-S, et al. Genetic analysis of murine models for rheumatoid arthritis. In: Adolpho KW, editor. Human Genome Methods. New York: CRC press; 1998. p. 215-38.
5. Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012;14(4):R191.
6. Malmström V, Michaëlsson E, Burkhardt H, Mattsson R, Vuorio E, Holmdahl R. Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis. Proc Natl Acad Sci U S A. 1996;93(9):4480-5.
7. Hultqvist M, Bäcklund J, Bauer K, Gelderman KA, Holmdahl R. Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice. J Immunol. 2007;179(3):1431-7.
8. Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, et al. Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum. 2008;58(7):2000-11.
9. Carlsén S, Hansson AS, Olsson H, Heinegård D, Holmdahl R. Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin Exp Immunol. 1998;114(3):477-84.
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Vacara cat#10020 Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)
￥3000
