- ￥2500 - 13800
- KEL Biotech
- ErbB3-H1001
- 中国
- 2025年12月07日
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- 详细信息
- 技术资料
- 库存：
999
- 英文名：
Recombinant Human ErbB3 (HER3) Protein (His Tag)
- 保质期：
3年
- 供应商：
上海聚顶生物科技有限公司
- 保存条件：
-20℃
- 规格：
100ug/1mg
| 规格： | 100ug | 产品价格： | ￥2500.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥13800.0 |
Gene Name
HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85- sErbB3
Source
This product is recombinant human ErbB3 (HER3) expressed in human 293 cells (HEK293). It comprises amino acids Ser20-Thr643 (NP_001973.2) corresponding to the extracellular domain of ErbB3.
The predicted N-terminus is Ser20.
Molecular Characterization
C-terminal polyhistidine tag for purification.
Calculated molecular weight: 70.0 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4
Typically contains 5-8% trehalose, mannitol, and 0.01% Tween-80 as protectants before lyophilization Contact us for customized formulations or special requirements
Purity
≥ 95% as determined by SDS-PAGE ≥ 95% as determined by SEC-HPLC
Endotoxin
< 1.0 EU per μg of protein (LAL method)
SDS-PAGE
The recombinant Human ErbB3 protein, His-tag, was analyzed by SDS-PAGE under both reducing (R) and non-reducing (NR) conditions. The protein purity is ≥95.
SEC-HPLC
The purity of Human ErbB3, His-tag, is >95%. The molecular weight of the protein is approximately 75-100 kDa, as verified by SEC-HPLC.
Stability & Storage
Samples are stable for 12 months from the date of receipt when stored at -20。C to -80。C under sterile conditions Recommend aliquoting into smaller portions to avoid repeated freeze-thaw cycles
Reconstitution
Detailed reconstitution instructions are provided with the product
Typically, add sterile PBS or desired buffer to dissolve the lyophilized protein to the target concentration
Protein Description
ErbB3 (HER3, Human Epidermal Growth Factor Receptor 3) is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein contains a neuregulin-binding domain but lacks an active kinase domain, and therefore cannot mediate intracellular signal transduction via protein phosphorylation. However, when forming heterodimers with ErbB2 or other EGFR family members, ErbB3 participates in tyrosine phosphorylation, forming a receptor complex with high affinity that initiates downstream signaling pathways leading to cell proliferation or differentiation.
ErbB3 has been implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein exists in multiple isoforms derived from alternative splicing, including a secreted isoform that lacks the transmembrane region and can modulate the activity of the membrane-bound form.
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