背景资料:FUNCTION: Rev appears to act post-transcriptionally to relieve negative repression of Gag and Env production.
PTM: Phosphoprotein whose state of phosphorylation is mediated by a specific serine kinase activity present in the nucleus. Phosphorylated at separate regions by protein kinase CK2 and MAPK. Phosphorylation by CK2 could play a role in Rev down-regulation.
SUBCELLULAR LOCATION: Nuclear; accumulates in the nucleoli.