PTEN (phospho Ser380 / Thr382

PTEN (phospho Ser380 / Thr382 / Thr383) 抗体，PTEN (phospho Ser380 / Thr382 / Thr383) Antibody，PTEN (phospho Ser380 / Thr382 / Thr383) 抗体,PTEN (phospho Ser380 / Thr382 / Thr383) Antibody

产品名称：PTEN (phospho Ser380 / Thr382 / Thr383) 抗体-PTEN (phospho Ser380 / Thr382 / Thr383) Antibody

产品货号：PSI-79-132-0.1mg

产品规格：0.1mg

背景资料：Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3, 4, 5)P3 > PtdIns(3, 4)P2 > PtdIns3P > Ins(1, 3, 4, 5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

保存建议：PTEN (phospho Ser380 / Thr382 / Thr383) 抗体-PTEN (phospho Ser380 / Thr382 / Thr383) AntibodyStore antibody at -20℃ for up to one year

应用类型：WB, IHC, IF

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