背景资料:The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.